Effects; of Cck Receptor Agonists and Antagonists on Morphine-induced Antinociception in Mice
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چکیده
In the present study the effects of both CCK receptor agonists and antago nists on antinociception induced by morphine in the tail-flick test have been evalu ated. M orphine induced dose-dependent antinoci�eption in mice. The response of morphine was potentiated by sulfated cholecystokinin-8 (CCK-8S) but not by unsulfated cholecystokinin-8 (CCK-8U). The CCK receptor antagonists MK-329 and L-365, 260 decreased the potentiation of morphine antinociception induced by CCK-8S.·The antagonists even decreased the response induced by morphine in the pre5;ence ofCCK-8U. High doses ofMK-329 and L-365, 260 also potenti ated morphine's antinociception. Single administration of the CCK receptor ago nists CCK-8 and CCK-8U or CCK receptor antagonists did not elicit any re sponse in the tail-flick test. It is concluded that CCK receptor mechanisms are involved in the modulation of pain response and/or morphine antinociception. MJIRL Vol. 14, No.3, 261-266, 2000.
منابع مشابه
EFFECTS OF CCK RECEPTOR AGONISTS AND ANTAGONISTS ON MORPHINE-INDUCED ANTINOCICEPTION IN MICE
In the present study the effects of both CCK receptor agonists and antagonists on antinociception induced by morphine in the tail-flick test have been evaluated. M orphine induced dose-dependent antinociception in mice. The response of morphine was potentiated by sulfated cholecystokinin-8 (CCK-8S) but not by unsulfated cholecystokinin-8 (CCK-8U). The CCK receptor antagonists MK-329 and L-...
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